Clear obesity gene link 'found'
Scientists have found a clear genetic link to obesity
Scientists say they have identified the clearest genetic link to obesity yet. They found people with two copies of a "fat" version of a gene had a 70% higher risk of obesity than those with none, and weighed 3kg (6.5lb) more.
The work in Science by the Peninsula Medical School and Oxford University studied data from about 40,000 people.
The findings suggest that although improving lifestyle is key to reducing obesity, some people may find it harder to lose weight because of their genes.
The typical message has been that if you are overweight it is due to sloth and gluttony and it is your fault
Professor Andrew Chatterley
The authors say their work, funded by the Wellcome Trust, could improve understanding of obesity and eventually help prevent it, as well as an illness it is linked to.
Genome differences
Obesity is associated with an increased risk of type two diabetes, and the investigators first identified the FTO gene when looking for differences between the genomes of people with type two diabetes and people without diabetes.
People with type two diabetes were more likely to have a particular variant of the FTO gene, which was also shown to be linked to increased body weight.
The variant making people fatter differed from the other version of the FTO gene by a single mutation in the DNA sequence.
More here
http://news.bbc.co.uk/1/hi/health/6547891.stm
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Scientists say they have identified the clearest genetic link to obesity yet. They found people with two copies of a "fat" version of a gene had a 70% higher risk of obesity than those with none, and weighed 3kg (6.5lb) more.
The work in Science by the Peninsula Medical School and Oxford University studied data from about 40,000 people.
The findings suggest that although improving lifestyle is key to reducing obesity, some people may find it harder to lose weight because of their genes.



Professor Andrew Chatterley
The authors say their work, funded by the Wellcome Trust, could improve understanding of obesity and eventually help prevent it, as well as an illness it is linked to.
Genome differences
Obesity is associated with an increased risk of type two diabetes, and the investigators first identified the FTO gene when looking for differences between the genomes of people with type two diabetes and people without diabetes.
People with type two diabetes were more likely to have a particular variant of the FTO gene, which was also shown to be linked to increased body weight.
The variant making people fatter differed from the other version of the FTO gene by a single mutation in the DNA sequence.
More here
http://news.bbc.co.uk/1/hi/health/6547891.stm
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